Analytical Sciences

Abstract − Analytical Sciences, 32(5), 517 (2016).

Preparation and Application of Novel Magnetic Molecularly Imprinted Composites for Recognition of Sulfadimethoxine in Feed Samples
Min FENG,* Hengye LI,*,** Lin ZHANG,*** Jingyou ZHANG,* Jianping DAI,* Xiaojin WANG,* Lingli ZHANG,* and Yunji WEI*
*Huai’an Entry-Exit Inspection and Quarantine Bureau, No. 32 Beijing North Road, Qinghe, Huai’an 223001, China
**School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, No. 9 Yinbing Avenue, Tinghu, Yancheng 224000, China
***Yancheng Entry-Exit Inspection and Quarantine Bureau, No. 85 Kaifang Avenue, Tinghu, Yancheng 224000, China
Novel magnetic molecularly imprinted composites were prepared through a facile method using sulfadimethoxine (SDM) as template. The inorganic magnetic nanoparticles were linked with the organic molecularly imprinted polymer (MIP) through irreversibly covalent bond. So, the resulted composites showed excellent stability and reusability under acidic elution conditions. The magnetic MIP composites showed good selectivity, high binding capacity and excellent kinetics toward SDM. Adopting the magnetic MIP composites as extraction material, an off-line magnetic solid-phase extraction (SPE)/high performance liquid chromatography (HPLC) method was established. The calibration curve was linear in the range of 0.05 – 15 mg kg−1 (r2 = 0.9976). The LOD and LOQ were 0.016 and 0.052 mg kg−1, respectively, while the recoveries were in the range of 89.3 – 107.0%. These novel magnetic MIP composites may become a powerful tool for the extraction of template from complex samples with good efficiency.