Analytical Sciences

Abstract − Analytical Sciences, 28(11), 1037 (2012).

Placement of Nanospace on an Electrode for Biosensing
Hiroshi SHIIGI,* Shiho TOKONAMI,** Yojiro YAMAMOTO,*,*** and Tsutomu NAGAOKA*
*Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-2 Gakuencho, Naka, Sakai, Osaka 599-8570, Japan
**Nanoscience and Nanotechnology Research Center, Osaka Prefecture University, 1-2 Gakuencho, Naka, Sakai 599-8570, Japan
***GreenChem. Inc., 202, 930-1 Fukuda, Naka, Sakai 599-8241, Japan
Electrical and electrochemical methods are well established as very useful techniques in the field of biosensing because they can easily handle signals and devices. This paper provides an overview of biosensing using a nanometer-sized space functionally. Placed effectively on the electrode, the nanospace offers several advantages, such as increased sensitivity, improved selectivity, decreased response time, and the potential for instrument miniaturization. Given the impressive technological progress of nanospace biosensors and its growing impact on analytical science, this review offers an easy-to-understand presentation describing the history, recent advances, new methods, and future prospects of nanospace biosensors.