Analytical Sciences

A Wireless Magnetoelastic Sensor for Urinary 2-Naphthol Detection Based on the Precipitation of 2-Naphthol with Diazonium Salts

Yu-Kun YUAN,*,** Yong-Sheng WANG,* Xi-Lin XIAO,*** Jin-Hua XUE,* Gui-Rong LI,* Rong-Hui KANG,* Jin-Quan ZHANG,* and Lin-Fei SHI*

*College of Public Health, University of South China, Hengyang 421001, P. R. China
**The Clinical Laboratory of Chenzhou Fourth People’s Hospital, Chenzhou 423000, P. R. China
***College of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, P. R. China

A wireless magnetoelastic sensor has been developed for the determination of 2-naphthol (2-NAP) in human urine. This method is based on the precipitation of 2-NAP with diazonium salts produced by the diazo-reaction of sulfamethoxazole (SMZ) with nitrite under a weak alkaline condition, resulting in a descending of the resonance frequency of a wireless magnetoelastic sensor. The frequence shift values (ΔF) of the sensor were directly proportional to the concentration in the range of 1.13 – 139 μmol L⁻¹ for 2-NAP with a correlation coefficient of 0.997 and a detection limit of 0.340 μmol L⁻¹. The relative standard deviations were 2.38, 2.40 and 2.44%, and the average recovery was 107% (n = 6). The proposed method has additional advantages of being less time-consuming, low cost and remote query, and can be applied for real-time and in situ monitoring of 2-NAP in human urine. It would be a benefit to extend the scope of applications of magnetoelastic sensing techniques.

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