Analytical Sciences

Abstract − Analytical Sciences, 22(5), 685 (2006).

Electrochemical Characteristics of Gatifloxacin and Its Interaction with DNA
Ming GUO* and Qing-Sen YU**
*Department of Chemistry, Zhejiang Forestry University, LinAn 311300, China
**Department of Chemistry, Zhejiang University, Hangzhou 310027, China
The electrochemical behavior of gatifloxacin (GTFX) and its interaction with natural calf thymus DNA (ctDNA) is investigated by differential pulse voltammetry (DPV) on a carbon paraffined electrode. According to the suggested electrochemical equation, a binding constant of 1.7058 × 105 (mol L-1)-1 and binding sizes s = 3.09 (base pairs) of GTFX with ctDNA are obtained by nonlinear fit analysis of electrochemical data. The results demonstrate that GTFX has the properties of an intercalative binder.