Analytical Sciences

Abstract − Analytical Sciences, 19(5), 691 (2003).

Determination of Dipyrone in Pharmaceutical Products by Flow Injection Analysis with Potentiometric Detection
Jackson S. ALBUQUERQUE,* Valdinete L. SILVA,*  Fernando LIMA,* Alberto N. ARAÚJO,** and Maria Conceição B. S. M. MONTENEGRO**
*Department of Chemical Engineering/Environmental Engineering and Quality Laboratory-UFPE, 50740-521-Recife, Brazil
**CEQUP/Department of Physical Chemistry, Faculty of Pharmacy, Rua Aníbal Cunha 164, 4050-Porto, Portugal
This work describes an FIA potentiometric procedure for the quantification of dipyrone in pharmaceutical products. For the detector, a tubular electrode comprising a polymeric membrane containing tetraoctylammonium as an electroactive material (5% w/w), dibutylphtalate as a mediator solvent (65% w/w) and PVC (30% w/w) directly applied above a graphite conductor support was used. This unit was incorporated into a monochannel FI-system with a 0.1 mol/L phosphate buffer solution (pH = 5.2) as the carrier solution. The electrode showed a linear response from 8.0 x 10-4 to 10-1 mol/L dipyrone, a slope of 62.1 ± 0.2 mV/dec in pH 5.2 units, an injection volume of 500 µL and a carrier flow-rate of 6 mL/min. This procedure was applied to the analysis of pharmaceutical formulations (oral and injectable) containing dipyrone; the obtained results gave a relative error of less than 3.9% and coefficients of variation less than 1% and 5%, respectively, for the FIA and classical iodometric methods.