Analytical Sciences

Abstract − Analytical Sciences, 19(4), 629 (2003).

Simple Method of Paroxetine Determination Using a Single Channel FIA with No In-line Reaction Process
Göksel ALTIOKKA and Kevser KIRCALI
Department of Analytical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey
A flow-injection analysis (FIA) of paroxetine hydrochloride (PRX), a selective serotonin reuptake inhibitor (SSRI) currently used as an antidepressant drug, is described. A 0.1 mol dm-3 acetate buffer at pH 3.07 was found to be the best solvent. The analyte was detected at 293 nm. The calibration equation was linear over the range of 1.07 x 10-6 to 5.35 x 10-6 mol dm-3. The limit of detection (LOD) and the limit of quantitation (LOQ) were 3.2 x 10-7 and 9.5 x 10-7 mol dm-3, respectively. The proposed method was applied to the determination of PRX in pharmaceutical preparations. The results were compared with those obtained by a conventional batchwise UV-spectrophotometry.