Analytical Sciences

Abstract − Analytical Sciences, 19(4), 625 (2003).

Flow-Injection Determination of Ornidazole by Chemiluminescence Detection Based on a Luminol-Ferricyanide Reaction
Yi LV, Zhujun ZHANG,  Deyong HE, and Yufei HU
Institute of Analytical Science, Department of Chemistry, Southwest Normal University, Beibei, Chongqing 400715, P. R. China
A flow-injection analysis (FIA) with a chemiluminescence detection method was developed for the determination of ornidazole based on the inhibition intensity of chemiluminescence from the luminol-ferricyanide system. Under the condition of 1.0 x 10-3 mol/L luminol and 5.0 x 10-6 mol/L potassium ferricyanide, the response to the concentration of ornidazole is linear from 0.2 µg ml-1 to 10 µg ml-1, and a detection limit of 0.05 µg ml-1 can be obtained. This method has been successfully applied to the determination of ornidazole in pharmaceutical preparations.