Analytical Sciences

Abstract − Analytical Sciences, 37(9), 1305 (2021).

Gold–Silver and Gold–Palladium Alloy Nanoparticles as Mass-Probes for Immunosensing
Maiko AKASAKA, Tomoki NISHI, and Yasuro NIIDOME
Department of Chemistry and Bioscience, Graduate School of Science and Engineering, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-8580, Japan
Silver or palladium shelled gold nanoparticles were fused into alloy nanoparticles by pulsed-laser irradiation. The alloy nanoparticles could carry antibodies on their surfaces without affecting their immune functionalities and interact selectively with antigens on a blotting membrane. Silver or palladium ions desorbed from the alloy nanoparticles as reporter ions upon the UV laser irradiation in a mass spectrometer.