Analytical Sciences

Abstract − Analytical Sciences, 37(4), 599 (2021).

Tannic Acid Capped Copper Nanoclusters as a Cost-Effective Fluorescence Probe for Hemoglobin Determination
Sonia SAM, Sanu K. ANAND, Manna Rachel MATHEW, and Krishnapillai Girish KUMAR
Department of Applied Chemistry, Cochin University of Science and Technology, Kochi-682022, Kerala, India
For the first time, we report on a copper nanoclusters based fluorescence sensor for hemoglobin (Hgb). The aggregation-induced quenching of tannic acid capped copper nanoclusters’ (TACuNCs) fluorescence by a Hgb-H2O2 mixture that mimics the Fenton’s reagent is used here for the selective determination of Hgb. It is possible to effectively determine Hgb using this sensitive and cost-effective sensor in the linear range of 5.0 × 10−8 to 4.0 × 10−9 M with a detection limit of 5.6 × 10−10 M. The practical utility of the sensor is evident from the good recovery values obtained from Hgb spiked with artificial blood serum.