Analytical Sciences

Abstract − Analytical Sciences, 37(4), 575 (2021).

Highly Sensitive Electrochemical Detection of Folic Acid by Using a Hollow Carbon Nanospheres@molybdenum Disulfide Modified Electrode
Huiming YE,*1 Liang SONG,*2,*3 Fuhui ZHANG,*1 Juan LI,*1 Zhiying SU,*4 and Yun ZHANG*2,*3,*5
*1 Department of Clinical Laboratory, Women and Children’s Hospital, School of Medicine, Xiamen University
*2 CAS Key Laboratory of Design and Assembly of Functional Nanostructures, and Fujian Provincial Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, China
*3 Department of Translational Medicine, Xiamen Institute of Rare-earth Materials, Haixi Institutes, Chinese Academy of Sciences, Xiamen, China
*4 Department of Obstetrics and gynecology, Women and Children’s Hospital, School of Medicine, Xiamen University
*5 University of Chinese Academy of Sciences, Beijing, China
As a nutrient in body functions, folic acid (FA) plays a very important role for human health, and thus developing a highly sensitive method for its determination is of great significance. In the present work, carbon hollow nanospheres decorated with molybdenum disulfide nanosheets (CHN@MoS2) nanomaterials were produced through a simple method and adopted to modify a glassy carbon electrode for assembling a highly sensitive electrochemical sensor of FA. After characterizing the prepared nanomaterials using scanning-/transmission-electron microscopy and Raman spectra, as well as optimizing various testing conditions, including the pH value of the buffer solution, the accumulation time and amount of nanomaterials on electrode surface, and the electrochemical determination of FA was carried out using a CHN@MoS2 electrode. Owing to the coordinative advantages from CHN and MoS2, the results show that CHN@MoS2 exhibits excellent sensing responses for FA, and it has a wide linear range from 0.08 to 10.0 μM coupled with a low detection limit of 0.02 μM. Finally, the proposed method for FA detection was successfully applied in human urine analysis. The obtained results are satisfactory, revealing that the developed method based on CHN@MoS2 nanomaterials has important applications for FA determination.