Analytical Sciences

Abstract − Analytical Sciences, 37(3), 519 (2021).

Bio-inert Properties of TEG Modified Dendrimer Interface
Yoshiko MIURA, Yuki KOJIMA, Hirokazu SETO, and Yu HOSHINO
Department of Chemical Engineering, Kyushu University, 744 Motoka, Nishi, Fukuoka 819-0395, Japan
The bioinert interfaces that prevent adhesion of proteins and cells are important for biomaterial applications. In order to design a bioinert interface, the immobilization of an appropriate functional group and the control of molecular density is required. Dendrimer was modified with triethylene glycol (TEG) to display a dense brush structure. TEG with different density and terminal groups were immobilized with a dendrimer template and thiol terminated molecules. The inhibitory effect on protein and bacteria binding was investigated. The physical property of the interface was measured by QCM-admittance to clarify the factor of the bioinert property.