Analytical Sciences

Abstract − Analytical Sciences, 36(3), 367 (2020).

A Fluorescently Ratiometric Natural Probe for Selective Detection of Sulfur Dioxide Derivative and Host-Guest Supramolecular Regulation
Xingyu TONG, Ting YE, Yali YU, Longlong GAO, Yifan FEI, Qingqing ZHANG, Heng GAO, Chenxiao YAN, and Yong SHAO
Institute of Physical Chemistry, College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, Zhejiang, China
Natural sanguinarine (SG) was first used as a fluorescent probe to develop a novel ratiometric sensor for selective HSO3 detection. The nucleophilic addition reaction of HSO3 occurs at the C=N+ group of SG, and subsequent breakage of the conjugated π cycle leads to a decrease in the SG iminium fluorescence that is accompanied by an increase in the alkanolamine fluorescence. Therefore, a ratiometric fluorescence method with a large wavelength shift can be established for HSO3 detection. Furthermore, cucurbit[8]uril was used as an efficient host to encapsulate SG for an improved selectivity for HSO3 detection over H2S. Our method benefits include little interference from other common anions and cations for HSO3 detection, suggesting a promising application in real sample analysis. Besides sensor development, the interaction of the natural SG with HSO3 was first demonstrated in this work to further get an insight into SG’s pharmacology.