Analytical Sciences

Abstract − Analytical Sciences, 35(12), 1305 (2019).

A Near-infrared Fluorescent Probe of Dicyanoisophorone Derivatives for Selective Detection and Fluorescence Cellular Imaging of Palladium
Hanshu WU,* Xiaojun YANG,** Jinxia MEN,* Huibin ZHANG,*** and Jinpei ZHOU*
*Department of Medicinal Chemistry, China Pharmaceutical University, Tongjia Xiang 24, Nanjing 210009, P. R. China
**Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, P. R. China
***Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing 210009, P. R. China
Palladium (Pd) has been acknowledged to be a rare inner transition metal, which plays a pivotal role in many fields. This article focuses on developing a safe and effective near-infrared fluorescent probe, MW-PD, which would make a great contribution to the detection of palladium residue in drugs, especially trace residues. The fluorescent probe was rationally designed by combining the dicyanoisophorone fluorophore with an allyloxycarbonyl group. Based on the Tsuji–Trost reaction, the probe exhibited high selectivity and sensitivity toward Pd (0) over other common metal ions with a low detection limit (8.0 nM). Moreover, MW-PD showed biocompatibility and was successfully applied to imaging Pd (0) in Hela cells.