Analytical Sciences

Abstract − Analytical Sciences, 35(1), 103 (2019).

Fabrication of a Flexible Biosensor Based on an Organic Field-effect Transistor for Lactate Detection
Tsukuru MINAMIKI,*,** Shizuo TOKITO,*** and Tsuyoshi MINAMI*
*Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8505, Japan
**Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan
***Research Center for Organic Electronics (ROEL), Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata 992-8510, Japan
A novel flexible lactate sensor based on organic field-effect transistors (OFETs) is demonstrated. Because lactate is known as a biomarker for assessing our physical performance, wearable lactate sensors could contribute to the monitoring of human health conditions. The flexible and low-voltage operatable OFET possesses an extended-gate modified with enzymes and an osmium-redox polymer for the lactate detection, meaning that the continuous measurement of lactate levels (0 – 10 mM) has been successfully achieved. We believe that insight obtained will open up opportunities for applying OFETs in wearable biosensors.