Analytical Sciences

Abstract − Analytical Sciences, 32(4), 473 (2016).

Imaging Mass Spectrometry Reveals a Decrease of Cardiolipin in the Kidney of NASH Model Mice
Takahiro HAYASAKA, Hirotoshi FUDA, Shu-Ping HUI, and Hitoshi CHIBA
Laboratory for Advanced Lipid Analysis, Health Innovation & Technology Center, Faculty of Health Sciences, Hokkaido University, Kita 12, Nishi 5, Kita, Sapporo, Hokkaido 060-0812, Japan
Non-alcoholic steatohepatitis (NASH) can be complicated with chronic kidney disease (CKD). In this study, changes in the distribution of biomolecules in the kidney were studied in NASH model mice with the use of imaging mass spectrometry (IMS). The mass spectra and ion images of IMS showed that the signals of cardiolipin (CL) species were decreased in the kidney cortex of the NASH mice. The decrease of CL might therefore suggest the kidney involvement of NASH.