Analytical Sciences

Abstract − Analytical Sciences, 29(11), 1035 (2013).

Laser Desorption Ionization Mass Spectrometry of Bioactive Substances by Using 2,4,6-Trihydroxyacetophenone on Cation-substituted Zeolite
Takashi ASANO,* Junya SUZUKI,** Kenro HASHIMOTO,** and Tatsuya FUJINO**
*Criminal Investigation Laboratory, Metropolitan Police Department, 2-1-1 Kasumigaseki, Chiyoda, Tokyo 100-8929, Japan
**Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University, 1-1 Minami-Osawa, Hachioji, Tokyo 192-0397, Japan
By using 2,4,6-trihydroxyacetophenone adsorbed to cation-substituted zeolite, laser desorption/ionization mass spectrometry for six kinds of bioactive substances was carried out. The compounds, which were usually difficult to observe by conventional matrix-assisted laser desorption/ionization mass spectrometry, were ionized by cation adduction from the zeolite surface.