Analytical Sciences

Abstract − Analytical Sciences, 26(10), 1065 (2010).

Electrochemical Monitoring of the Interaction between 4-Nonylphenol and DNA by Graphite and Carbon Nanotube Modified Graphite Electrodes
Hakan KARADENIZ,* Ayfer CALISKAN,* and Cevdet UGUZ**
*Department of Analytical Chemistry, Faculty of Pharmacy, Ege University, 35100, Bornova, Izmir, Turkey
**Department of Medical Biology and Genetics, Faculty of Veterinary Medicine, Afyon Kocatepe University, 03200 Afyonkarahisar, Turkey
The interaction of 4-nonylphenol (NP) with deoxyribonucleic acid (DNA) was explored electrochemically by using differential pulse voltammetry (DPV) in combination with unmodified and modified pencil graphite electrodes (PGE) with single walled carbon nanotubes (SWCNT). The differentiation of the two oxidation signals coming from NP and DNA base, guanine was studied before and after the interaction process. In addition, the effect of NP concentration was investigated in order to determine the optimum experimental conditions. The detection limit and the reproducibility were determined by using CNT-modified electrodes.