Analytical Sciences

Abstract − Analytical Sciences, 25(11), 1373 (2009).

Simultaneous LC/MS Analysis of Hexachlorobenzene and Pentachlorophenol by Atmospheric Pressure Chemical Ionization (APCI) and Photoionization (APPI) Methods
Issey OSAKA,* Arifumi YOSHIMOTO,** Kazuyoshi NOZAKI,** Hiroshi MORIWAKI,***Hideya KAWASAKI,** and Ryuichi ARAKAWA**
*Center for Nano Materials and Technology, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1294, Japan
**Department of Chemistry and Material Engineering, Kansai University, 3-3-35 Yamate, Suita, Osaka 564-8680, Japan
***Division of Applied Biology, Faculty of Textile Science and Technology, Shinshu University, 3-15-1 Tokita, Ueda, Nagano 386-0567, Japan
The simultaneous LC/MS analyses of hexachlorobenzene (HCB) and pentachlorophenol (PCP), two dioxin precursors were studied by both atmospheric pressure chemical ionization (APCI) and atmospheric pressure photoionization mass spectrometry (APPI/MS). The optimum LC/MS conditions of the simultaneous analysis were determined for these two compounds with different polarity. Ionization by APPI was found to be more effective than by APCI, and is thus a better ionization method for analysis of the two compounds. Using LC/APPI/MS we can achieve the simultaneous analysis of HCB and PCP at ppb levels.