Analytical Sciences

Abstract − Analytical Sciences, 24(1), 31 (2008).

Development of Highly Potent Chiral Discrimination Methods That Solve the Problems of Diastereomer Method
Hiroshi OHRUI
Yokohama College of Pharmacy, 601 Matano-cho, Totsuka, Yokohama 245-0066, Japan
The development of highly potent chiral discrimination methods that solve the problems of the diastereomer method is described. Explaining the significant results of separations of diastereomers having chiral centers separated by 13 - 27 bonds with reversed-phase HPLC was hitherto impossible. To attract more scientific interest toward the mechanism of the separation, the author proposes a hypothesis, Induced Chiral Fields, that the achiral reversed phases can provide chiral fields depending on the structures of the substrates.