Analytical Sciences

Abstract − Analytical Sciences, 23(1), 21 (2007).

Quantum Dots for Single Bio-Molecule Imaging
Noritada KAJI,*1,*2 Manabu TOKESHI,*1,*2 and Yoshinobu BABA*1,*2,*3,*4
*1 Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan
*2 MEXT Innovative Research Center for Preventive Medical Engineering, Nagoya University, Nagoya 464-8603, Japan
*3 Plasma Nanotechnology Research Center, Nagoya University, Nagoya 464-8603, Japan
*4 National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu 761-0395, Japan
The emerging nanomaterial, quantum dots or QDs, offers numerous potential applications in the biological area. As cell labeling probes, QDs become now an alternative of existing organic fluorescent dyes and fluorescent proteins. In this short review, we cover typical and successful applications of QDs as fluorescent probes in cell labeling and genomic diagnosis. As a future important application, biomolecular detection at a single molecule level utilizing QDs is also discussed.