Analytical Sciences

Abstract − Analytical Sciences, 22(1), 183 (2006).

Determination of Ceftriaxone Sodium in Pharmaceutical Formulations by Flow Injection Analysis with Acid Potassium Permanganate Chemiluminescence Detection
Deyi ZHANG,* Yongjun MA,* Min ZHOU,* Li LI,* and Hui CHEN**
*Institute of Chemistry, Northwest Normal University, Lanzhou 730070, P. R. China
**Gansu Key Laboratory of Polymer Materials, Lanzhou 730070, P. R. China
Based on the chemiluminescence (CL) emission generated from the oxidation of ceftriaxone sodium alkali hydrolysate by potassium permanganate in polyphosphoric acid (PPA), a novel determination method for ceftriaxone sodium was developed by using a flow-injection technique. The calibration curve appears to be linear in the range between 0.05 and 100 µg mL-1 with a detection limit (3 σ) of 25 ng mL-1, and a relative standard deviation (RSD) of 0.6% for eleven replicate determinations of 5.0 µg mL-1 ceftriaxone sodium. The proposed method has been successfully utilized for the determination of ceftriaxone sodium in pharmaceutical formulations, while the chemiluminescence reaction mechanisms were investigated.