Analytical Sciences

Phenylboronic Acid-based ¹⁹F MRI Probe for the Detection and Imaging of Hydrogen Peroxide Utilizing Its Large Chemical-Shift Change

Hiroshi NONAKA,* Qi AN,* Fuminori SUGIHARA,** Tomohiro DOURA,* Akira TSUCHIYA,* Yoshichika YOSHIOKA,** and Shinsuke SANDO*

*INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi, Fukuoka 819-0395, Japan
**Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan

Herein, we report on a new ¹⁹F MRI probe for the detection and imaging of H₂O₂. Our designed 2-fluorophenylboronic acid-based ¹⁹F probe promptly reacted with H₂O₂ to produce 2-fluorophenol via boronic acid oxidation. The accompanying ¹⁹F chemical-shift change reached 31 ppm under our experimental conditions. Such a large chemical-shift change allowed for the imaging of H₂O₂ by ¹⁹F chemical-shift-selective MRI.

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